Bald Truth: Mouse Study May Get at Roots of Hair Loss

Bald Reality: Mouse Research Might Get at Roots of Hair Loss

By Robert Preidt
HealthDay Reporter

THURSDAY, Oct. 28, 2021 (HealthDay Information) — New analysis in mice could present clues to age-related hair loss in women and men.

Scientists discovered that as hair stem cells in mice age, they lose the stickiness that retains them secured contained in the hair follicle. This enables the stem cells to float away from the follicle.

“The result’s fewer and fewer stem cells within the hair follicle to provide hair,” mentioned examine lead creator Rui Yi, a professor of pathology at Northwestern College Feinberg Faculty of Medication, in Chicago. This results in thinning hair and baldness throughout getting old, he famous.

The researchers additionally recognized genes that will regulate hair stem cell adhesion. And so they created mice that lacked two of the genes, FOXC1 and NFATC1.

The mice with out these genes began shedding hair quickly at 4 months and had been fully bald inside 12 to 16 months, based on the examine. The outcomes had been revealed in October within the journal Nature Growing older.

Mice and people share many similarities in hair and stem cells, so these discovering could apply to older women and men with thinning hair, Yi instructed. Nonetheless, analysis in animals would not all the time pan out in people.

“We consider this stem cell escape mechanism has by no means been reported earlier than, as a result of no one might monitor the getting old course of in dwell animals,” Yi mentioned in a college information launch.

It was recognized that hair follicles shrink with age, nevertheless it wasn’t clear how that occurred. Many specialists believed it was as a consequence of cell demise or cells’ incapacity to divide as they age.

“We found, at the least partially, it is because of hair follicle stem cells migrating away from their area of interest,” Yi mentioned. Noting that cell demise additionally occurred throughout their statement, he added, “Our discovery would not dispute present theories however gives a brand new mechanism.”

In a brand new examine, the researchers are attempting to reinstate the FOXC1 and NFATC1 genes to seek out out if doing so will reverse hair loss.

Extra info

The American Academy of Dermatology Affiliation has extra on hair loss.

SOURCE: Northwestern College, information launch, Oct. 26, 2021

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