Enhanced external counterpulsation offers potential treatment option for long COVID patients

Enhanced exterior counterpulsation provides potential therapy choice for lengthy COVID sufferers

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In a small research of lengthy COVID-19 sufferers, these with and with out coronary artery illness demonstrated enchancment of a wide range of signs, together with fatigue, respiration difficulties and chest discomfort, after present process 15-35 hours of enhanced exterior counterpulsation (EECP) remedy. The research is being offered on the American Faculty of Cardiology’s Cardiovascular Summit digital convention on Feb. 16-19, 2022.

EECP is a non-invasive method proven to enhance cardiac and cerebral perfusion. Sufferers present process EECP arrive on the clinic to put on a therapy desk and are fitted with three units of pneumatic cuffs on the calves, thighs and decrease hip space. A 3-lead electrocardiogram is used because the mechanism for the cuffs to inflate sequentially, from the calves as much as the hips throughout the resting section of the guts. On the onset of the contraction section of the guts, the cuffs deflate on the similar time. This prescribed inflation and deflation pushes oxygen-rich blood all through the guts muscle and the remainder of the physique. A affected person undergoes a therapy session for one hour, with as much as 35 therapy classes over the course of seven weeks.

“Rising information reveals that lengthy COVID is a illness that impacts the well being of vessels, also called endothelial operate. EECP is a disease-modifying, non-invasive remedy that has beforehand proven to enhance endothelial operate in managed medical trials,” mentioned Sachin A. Shah, PharmD, senior writer on the research and chief scientific officer at Circulation Remedy, a nationwide EECP supplier headquartered in Ft. Price, Texas. “We presently consider that that is probably the most believable rationalization for the advantages derived from EECP and the hyperlink to lengthy COVID.”

Globally, an estimated 50% of COVID-19 sufferers expertise lingering signs six months after the acute section of COVID-19 an infection, with the long-term signs various in severity.

“A number of of our sufferers have been disabled to the purpose of not having the ability to work,” Shah mentioned. “Remarkably, all sufferers at this level have been capable of efficiently return again to work after present process therapy. These sufferers additionally confirmed enchancment in ‘mind fog,’ which is a typical symptom of lengthy COVID. We’re enthusiastic about persevering with to research this information and share it sooner or later.”

Researchers included 50 lengthy COVID sufferers (54±15 years previous) referred to a Circulation Remedy supplier for EECP therapy in a retrospective evaluation, together with 30 sufferers with no historical past of coronary artery illness and 20 sufferers with coronary artery illness (CAD). All sufferers have been assessed pre- and post-EECP remedy utilizing the Seattle Angina Questionnaire-7 (SAQ7), Duke Exercise Standing Index (DASI), PROMIS Fatigue Instrument (PROMIS), Rose Dyspnea Scale (RDS) and 6-minute stroll take a look at (6MWT).

“These exams have been used as they’re all validated instruments accepted by the Worldwide Consortium for Well being Outcomes Measurement to evaluate fatigue, respiration difficulties and chest discomfort,” Shah mentioned.

“They’ve been utilized in medical trials to evaluate illness burden and are related to morbidity and mortality advantages,” he mentioned.

The evaluation discovered statistically important enhancements throughout all validated testing instruments:

  • Well being Standing utilizing the SAQ7 device improved by 25 factors (Vary 0-100)
  • Purposeful capability utilizing the DASI evaluation improved by 20 factors (vary 0-58.2)
  • Fatigue ranges utilizing the PROMIS rating decreased by 6 factors (Vary 4-20)
  • Shortness of Breath utilizing the RDS decreased in 50% of sufferers
  • Strolling capability (6MWT) in 6 minutes elevated by 178 ft

Researchers discovered the change from baseline for sufferers with lengthy COVID solely was important for all endpoints and no distinction was evident between sufferers with lengthy COVID with out CAD in comparison with these with CAD.

In line with the researchers, bigger research with a sham-control group are justified to additional validate these findings.



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Enhanced exterior counterpulsation provides potential therapy choice for lengthy COVID sufferers (2022, February 14)
retrieved 14 February 2022
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