First human case of avian influenza A(H5N1) in Europe

First human case of avian influenza A(H5N1) in Europe

First human case of avian influenza A(H5N1) in Europe
Map of excessive pathogenicity avian influenza H5N1-infected premises and wild hen occasions, Nice Britain, October 2021–January 2022. Credit score: Eurosurveillance

Following an outbreak of extremely pathogenic avian influenza A(H5N1) in a flock of round 125 Muscovy geese in a home setting in South West England on 22 December 2021, the virus was later additionally confirmed within the asymptomatic flock proprietor.

Whereas transmission of avian influenza viruses from birds to people is usually uncommon, these viruses might adapt and acquire the power to additionally unfold from individual to individual. Well timed identification of human an infection is thus important to forestall additional unfold.

Of their fast communication, Oliver et al. describe the scientific epidemiological and virological features of this primary human case of avian influenza A(H5N1) in Europe. In Nice Britain, the autumn/winter 2021/22 season has seen the biggest ever variety of extremely pathogenic avian influenza A(H5N1) wild hen detections and poultry outbreaks since 2003.

Influenza A(H5N1) was confirmed in 19 out of 20 sampled stay birds from the flock on 22 December 2021. The flock proprietor had been in shut contact with the contaminated birds with none private protecting gear however remained asymptomatic throughout an prolonged remedy course of antiviral medicine (oseltamivir) for 10 days till two consecutive Polymerase chain response (PCR) assessments have been unfavourable. Throughout that point, the well being authorities initiated complete contact tracing amongst 11 human contacts. Amongst these contacts no further main circumstances or secondary transmissions have been noticed.

Through the investigation, the sequences of all gene segments from the human virus pressure have been in contrast with these of the duck virus and the evaluation confirmed that the H5N1 within the flock proprietor’s respiratory materials was an identical in all segments to the avian sequence, other than 4 nucleotide (nt) mutations.

Based on the authors, “the circumstances relating to publicity to birds have been uncommon, with a excessive diploma of shut contact with numerous contaminated birds and a virus-contaminated enclosed home surroundings which resulted in an infection. The spill-over an infection to the human contact didn’t result in any detected genetic modifications within the virus that could be related to elevated zoonotic threat. This case demonstrates the elevated threat posed by this type of shut contact however doesn’t change the general evaluation that the danger to most of the people from avian influenza virus stays very low.”

The analysis was printed in Eurosurveillance.

Extra data:
Isabel Oliver et al, A case of avian influenza A(H5N1) in England, January 2022, Eurosurveillance (2022). DOI: 10.2807/1560-7917.ES.2022.27.5.2200061

Offered by
European Centre for Illness Prevention and Management (ECDC)

First human case of avian influenza A(H5N1) in Europe (2022, February 4)
retrieved 5 February 2022

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